Tit Bits



Why metastasic cells migrate?

One of the most intriguing questions in cancer research is what causes metastatic tumour migration, why some tumour cells manage to migrate to other parts of the body but others cells don't. International investigation conducted by Enrique Martín Blanco, CSIC researcher at the Institute of Biology of Barcelona, located in the Barcelona Science Park, reveals that cells make use of a natural mechanism for this. It happens to be a family of proteins that trigger cell migration in normal processes such as growth or healing. Nevertheless, this mechanism had never been identified before in healthy cells.

Windpipe transplant

A 10-year-old British boy has become the first child to undergo a windpipe transplant with an organ crafted from his own stem cells.
It is hoped that using the boy's own tissue in the nine-hour operation at Great Ormond Street Hospital will cut the risk of rejection.
The world's first tissue-engineered windpipe transplant was done in Spain in 2008 but with a shorter graft. 




MRI Vs CT in Ear Disease
MRI is superior to CT for the evaluations of infected cholesteatomas, petrous apex, and CPA cholesteatomas, as well as for the majority evaluation of cholesteatomatous involvement of the facial nerve, membranous labyrinth, and intracranial structures


Nasal Sprays & Addiction
True addiction is a compulsive physiological need for and use of a habit-forming substance known to be physically, psychologically or socially harmful. Over-the-counter nasal sprays don't contain any habit-forming ingredients, and they don't cause the compulsive cravings that mark an addiction.


The Hybrid System
Hybrid System seamlessly blends two well-established technologies - cochlear implants and hearing aids - for individuals with severe to profound high frequency hearing loss, who maintain their low frequency hearing. It integrates cochlear implant technology from Cochlear, with state-of-the-art hearing aid technology. The higher frequency regions of the cochlea are stimulated electrically, while lower frequencies are preserved for acoustic amplification. By effectively restoring the severe to profound high frequency loss using electrical stimulation, Hybrid enables individuals to regain their ability to communicate easily and enhances their appreciation of environmental sounds.


Alloplasts in Rhinoplasty
In Europe the recommendations do not support the use of alloplastic implant, complications in the medical literature are 6% for silicone and 4% for Medpor (polyethylene), the alloplasts is not permitted in France as in the USA


Dr Lionel Azan ( paris )
Link


Botox
Botulinum toxin is a medication and a neurotoxic protein produced by the bacterium Clostridium botulinum, and is held to be the most toxicprotein known to mankind[with an LD50 of ro ghly 0.005–0.05 µg/kg. Despite its deadly toxic effect, it is sometimes used in very small doses to treat muscle spasms. Popularly known by its trade name, Botox, botulinum toxin is now commonly used in various settings for cosmetic procedures.


Artificial muscles for facial palsy
Surgeons from UC Davis Medical Center have demonstrated that artificial muscles can restore the ability of patients with facial paralysis to blink, a development that could benefit the thousands of people each year who no longer are able to close their eyelids due to combat-related injuries, stroke, nerve injury or facial surgery.
In addition, the technique, which uses a combination of electrode leads and silicon polymers, could be used to develop synthetic muscles to control other parts of the body. The new procedure is described in an article in the January-February issue of the Archives of Facial Plastic Surgery.


link
Tracheal transplant
Belgian transplant surgeons are reporting a medical first: They coaxed a donor trachea to grow its own network of blood vessels before transplantation by first embedding it for months in the recipient's arm.
read more


Pseudohypacusis
Pseudohypacusis represents the most frequent etiology of sudden hearing loss in children. Its detection is relatively simple using conventional audiological tests though in some cases even experienced clinicians may come to incorrect diagnosis.


Researchers identify protein needed to develop auditory neurons
Loss of spiral ganglion neurons or hair cells in the inner ear is the leading cause of congenital and acquired hearing impairment. Researchers at the University of California, San Diego, School of Medicine and the National Institutes of Health found that Sox2, a protein that regulates stem cell formation, is involved in spiral ganglion neuron development. The study was published in the January 13 issue of the Journal of
Neuroscience.


Fact of the day
If you have a cold for fewer than 7 days, you can't tell if it's viral or bacterial. 7 or more days? It's bacterial.
Dr Ghagheri(Portland USA)




Nasal Carriers of Staphylococcus aureus
For over a century, the surgeon has covered his nasal vestibule to protect patients from micro-organisms, and although it also covered his mouth, in my day this would often be insufficient to prevent a constant stream of right-wing and sexist exhalation on the state of the world. But in fact several studies have shown that it is the patients' own nasal staphylococciwhich lead tosurgical site infections, just as many bring their own copies of the Sun or Express to succour them during their stay. If you detect these pathogens before admission, you can eliminate them and reduce staphylococcal wound infections. Ward newspaper trolleys must be the next target.


Sulcus vocalis
Sulcus vocalis is a thinning or absence of a special layer of tissue, called the superficial lamina propria, which is the tissue covering the vocal cord requires to vibrate in order to produce sound. The lack of this tissue causes a divot in the vocal cord, which gives the disorder its medical name.Sulcus means “cleft” or “furrow” in latin.


Barrett's esophagus
The normal lining of the esophagus (squamous epithelium) is replaced by an intestinal-type lining (columnar epithelium).


Drug Pump for tinnitis
A drug pump which is implanted in the ear is the latest approach for tackling tinnitus. It works by releasing a powerful new medicine that calms the overactive nerves thought to cause the condition. The new therapy, developed by U.S.-based company NeuroSystec, uses a drug known as NST-001 This is thought to block the production of excessive glutamate, in turn reducing this rogue nerve firing. Researchers claim it may even result in the elimination of tinnitus. Read more:


93 percent of Indians are sleep deprived !
A recent survey indicated that 93 percent of Indians are sleep deprived and 11 percent actually fall asleep in the work place.
The survey was conducted by the Nielsen company in 2009 and it covered 5,600 respondents (ages 35-65) across 25 cities in Urban India. It was commissioned by Philips Electronics India Limited.
58 percent of the respondents say that their work was affected by their lack of sleep. 74 percent claim that they woke up 1-3 times during their sleep.
62 percent of the respondents displayed a high risk of Obstructive Sleep Apnea (OSA), a condition that is characterized by repeated cessation of breathing during sleep and is also linked to heart disease and heart failure.
Source: The Economic Times


Lemierre syndrome
Lemierre syndrome is a rare disease of the head and neck often affecting adolescents and young adults. Classically, infection begins in the oropharynx with thrombosis of the tonsillar veins followed by involvement of the parapharyngeal space and the internal jugular vein. Septicemia and pulmonary lesions develop as infection spreads via septic emboli. Although a rare entity in modern times, Lemierre syndrome remains a disease of considerable morbidity and potential mortality.


Hearing Instrument Industry Showing Dynamic Market Integration
For decades, hearing instrument and cochlear implant companies have stayed focused on their respective market niches. Hearing aids have been marketed to people with mild, moderate, and severe hearing loss, and cochlear implant companies have focused on people with profound hearing loss. Now, both are actively seeking investment into the other’s market niches. Sonova, the parent holding company to Phonak of Switzerland, has just completed its acquisition of Advanced Bionics, a Valencia California company. AB makes cochlear implants, medical devices focused on electrical stimulation of the cochlea, allowing people with profound hearing loss the ability to hear and communicate. The cochlear implant, an implantable medical device, is the most sophisticated electrical neurostimulation prosthetic in distribution.

Silicone jaw implant preferred over medpor
Medpor is a very porous substance that when used is extremely difficult to remove. Silicone jaw implants are quite easily removable if ever necessary. Medpor has a higher rejection rate than silicone. Silicone jaw implants will give a better end result for long-term stability and less likely have infection.
Seattle Rhinopasty

Logopedics

The study and treatment of speech defects in children, involving habilitation or rehabilitation of speech.


Phoniatrics
The specialty is based on the anatomical, physiological, diagnostic and therapeutic principles of otorhinolaryngology and also on other medical disciplines (e.g. neurology, psychiatrics, pediatrics, dentistry, orthodontics) and non-medical sciences (e.g. linguistics, phonetics, psychology, behavior sciences, pedagogics, acoustics, communication sciences).


New material mimics bone to create better biomedical implants
A "metal foam" that has a similar elasticity to bone could mean a new generation of biomedical implants that would avoid bone rejection that often results from more rigid implant materials, such as titanium. Researchers at North Carolina State University have developed the metal foam, which is even lighter than solid aluminum and can be made of 100 percent steel or a combination of steel and aluminum. LINK


Why plastic surgeons are leaders in using the web to talk with patients
Connecting with an actual doctor, and getting an online quote for a procedure, are both appealing concepts — and foreign for many patients. Although there are many issues to be worked out, like offering advice over the web to someone you’ve never met and ensuring patient privacy, it’s clear that plastic surgeons have been the most aggressive physicians to utilize the web for marketing. Link


Tone deafness
Tone deafness (also known as amusia or dysmelodia) is the inability to differentiate between musical notes or lack of relative pitch. This kind of deafness is mostly genetic, but also can be a result of brain damage. Those people who are not able to discriminate music notes due to lack of musical training do not fall into this category. Research into this area revealed a lack of connection between the nerve fibres that link perception and motor areas.(Text from Audiology India)


MRI Vs CT in Ear Disease
MRI is superior to CT for the evaluations of infected cholesteatomas, petrous apex, and CPA cholesteatomas, as well as for the majority evaluation of cholesteatomatous involvement of the facial nerve, membranous labyrinth, and intracranial structures.


Nasal Sprays & Addiction
True addiction is a compulsive physiological need for and use of a habit-forming substance known to be physically, psychologically or socially harmful. Over-the-counter nasal sprays don't contain any habit-forming ingredients, and they don't cause the compulsive cravings that mark an addiction.


The Hybrid System
Hybrid System seamlessly blends two well-established technologies - cochlear implants and hearing aids - for individuals with severe to profound high frequency hearing loss, who maintain their low frequency hearing. It integrates cochlear implant technology from Cochlear, with state-of-the-art hearing aid technology. The higher frequency regions of the cochlea are stimulated electrically, while lower frequencies are preserved for acoustic amplification. By effectively restoring the severe to profound high frequency loss using electrical stimulation, Hybrid enables individuals to regain their ability to communicate easily and enhances their appreciation of environmental sounds.




Alloplasts in Rhinoplasty
In Europe the recommendations do not support the use of alloplastic implant, complications in the medical literature are 6% for silicone and 4% for Medpor (polyethylene), the alloplasts is not permitted in France as in the USA


Dr Lionel Azan ( paris )




Botox
Botulinum toxin is a medication and a neurotoxic protein produced by the bacterium Clostridium botulinum, and is held to be the most toxicprotein known to mankind[with an LD50 of ro ghly 0.005–0.05 µg/kg. Despite its deadly toxic effect, it is sometimes used in very small doses to treat muscle spasms. Popularly known by its trade name, Botox, botulinum toxin is now commonly used in various settings for cosmetic procedures.


Artificial muscles for facial palsy
Surgeons from UC Davis Medical Center have demonstrated that artificial muscles can restore the ability of patients with facial paralysis to blink, a development that could benefit the thousands of people each year who no longer are able to close their eyelids due to combat-related injuries, stroke, nerve injury or facial surgery.
In addition, the technique, which uses a combination of electrode leads and silicon polymers, could be used to develop synthetic muscles to control other parts of the body. The new procedure is described in an article in the January-February issue of the Archives of Facial Plastic Surgery.




Tracheal transplant
Belgian transplant surgeons are reporting a medical first: They coaxed a donor trachea to grow its own network of blood vessels before transplantation by first embedding it for months in the recipient's arm.




Pseudohypacusis
Pseudohypacusis represents the most frequent etiology of sudden hearing loss in children. Its detection is relatively simple using conventional audiological tests though in some cases even experienced clinicians may come to incorrect diagnosis.


Researchers identify protein needed to develop auditory neurons
Loss of spiral ganglion neurons or hair cells in the inner ear is the leading cause of congenital and acquired hearing impairment. Researchers at the University of California, San Diego, School of Medicine and the National Institutes of Health found that Sox2, a protein that regulates stem cell formation, is involved in spiral ganglion neuron development. The study was published in the January 13 issue of the Journal of Neuroscience.


Fact of the day
If you have a cold for fewer than 7 days, you can't tell if it's viral or bacterial. 7 or more days? It's bacterial.
Dr Ghagheri(Portland USA)



Nasal Carriers of Staphylococcus aureus



For over a century, the surgeon has covered his nasal vestibule to protect patients from micro-organisms, and although it also covered his mouth, in my day this would often be insufficient to prevent a constant stream of right-wing and sexist exhalation on the state of the world. But in fact several studies have shown that it is the patients' own nasal staphylococciwhich lead to surgical site infections, just as many bring their own copies of the Sun or Express to succour them during their stay. If you detect these pathogens before admission, you can eliminate them and reduce staphylococcal wound infections. Ward newspaper trolleys must be the next target.