Oto-toxic Drugs: List from House Ear Institute

Cinchona alkaloids
Minimum risk, usually temporary and reversible
Quinidine
Chloroquine
Quinine (Q-vel®)
Salycilates
Compounds containing Aspirin may cause hearing problems in high doses (20-30 tablets per day) though this is reversible.)
Acetaminophen
Aspirin
Anti-inflammatory Agents
Problems seen in patients with sensitivity, symptoms reversible
Pyrazolones
Ibuprofen (propionic acids)
Ascetic acids
Aminoglycosides
Listed in order of toxicity, these drugs are given only by IV/injection, not orally. They can affect either hearing, balance or both.
Neomycin
Streptomycin
Kanamycin
Amikacin, Gentamicin
Tobramycin
Netilmicin
Rinostamycin
Dihydrostreptomycin

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